Steroids and Genetics

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Can Steroids Change Your Genetics?

They can certainly change your future as the parade of modern bodybuilders who die very young continues to mount up huge numbers.

Most steroids typically don't alter your genetic makeup and you won't turn green and Hulk-like by taking them but there is discussion in the research community that some particular drugs may be able to alter your DNA to a certain degree. You won’t grow big calves if you are genetically predisposed to skinny calves, but some changes may indeed occur.

The process under consideration is that if the steroids, growth hormones and other similar chemicals alter your stem cells (germline stem cells used in the production of sperm) then that alteration will continue via the sperm for future reproduction and it may be that some genetic mutations or changes could possibly be passed on. Others dispute this.

Mutagenesis can come through chemical testosterone, methandrostenolone, and trenbolone. There is even research being conducted on animals to determine the outcome - for instance:

"Trenbolone growth promotant: covalent DNA binding in rat liver and in Salmonella typhimurium, and mutagenicity in the Ames test".

Other studies on trenbolone found that it does cause genetic changes and they are quite dramatic. A 2007 study found that trenbolone caused some cells to be killed and the remaining cells were strongly altered.

It is not necessarily a simple issue but more complex. There are a variety of factors to consider. These include the type of drugs used, how long they are used, and how they are stacked with other drugs.

And whether or not research eventually discovers for certain if steroids alter your genetics to some degree, it has been found that steroids can damage your DNA. They do so by damaging the white blood cells or lymphocytes, which affects the body’s immune system. This may be one of the reasons so many steroid users are in such poor health later in life.

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